Currently browsing posts about: Sponsored-research

A reader, Gema Flores Monreal, who holds a doctorate in Food Science and Nutrition, pointed me to this study.  She noted that it examines the effects on blood pressure of eating 5 to 6 servings of dairy per day, twice what is typically recommended. 

it is easy to understand why a dairy company would want research like this.  People are consuming less dairy food, and the industry wants to reverse the decline.

The study:  Effect of high compared with low dairy intake on blood pressure in overweight middle-aged adults: results of a randomized crossover intervention study.  Rietsema S, and 11 other authors.  Am J Clin Nutr 2019;110:340–348.

Conclusions: “This intervention study shows that an HDD [high dairy diet] results in a reduction of both systolic and diastolic BP [blood pressure] in overweight middleaged men and women. If the results of our study are reproduced by other studies, advice for high dairy intake may be added to treatment and prevention of high BP.”

Funding: “Supported by the Public–Private Partnership Topconsortium voor Kennis en Innovatie (TKI) Agri & Food (TKI-AF-12104).”  FrieslandCampina, a Dutch multinational dairy cooperative, is part of the partnership.  Two of the authors are employed by FrieslandCampina.

Comment: As I discuss in Unsavory Truth, research like this has a high probability of producing biased results.  I’m reserving judgment about dairy foods and blood pressure until results like these are confirmed by independent research.

Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial, Sheau C. Chai,, et al. Food Funct., 2019,10, 4423-4431.

Method: In this randomized controlled trial, 37 adults between the ages of 65–80 with normal cognitive function were recruited and randomly assigned to consume two cups of Montmorency tart cherry juice for 12 weeks.

Results: The within-group analysis showed that the visual sustained attention (p < 0.0001) and spatial working memory (p = 0.06) improved after the 12-week consumption of tart cherry juice compared with corresponding baseline values. Daily tart cherry juice consumption may improve cognitive abilities.

Conclusion: Our study demonstrated that daily intake of Montmorency tart cherry juice may help improve subjective memory and cognitive abilities in older adults as evidenced by increased contentment with memory, improved visual sustained attention and spatial working memory, and reduced movement time and total errors made on new learning tasks in older adults. T

Acknowledgements: The present study was supported by the Cherry Research Committee of the Cherry Marketing Institute, a non-profit organization. Tart cherry concentrates were provided by the Cherry Marketing Institute. Funders had no role in the study design, data collection, data analysis or interpretation, or writing of the manuscript.

Comment: I love cherries—a joy of summer—and wouldn’t it be wonderful if eating them was all you had to do to prevent cognitive decline.  Are cherries better than any other fruit or vegetable for this purpose?  This study did not examine that question but eating a healthy diet is always a good idea.  As for funders having no role, they don’t have to.  The mere fact that they funded this study skews the research question, as much evidence demonstrates (I reviewed this evidence in Unsavory Truth).

The study: Recent Research on the Health Benefits of Blueberries and Their Anthocyanins.   Wilhelmina Kalt, Aedin Cassidy, Luke R Howard, Robert Krikorian, April J Stull, Francois Tremblay,Raul Zamora-Ros.   Advances in Nutrition, nmz065, https://doi.org/10.1093/advances/nmz065

Abstract conclusion: More evidence, and particularly human clinical evidence, is needed to better understand the potential for anthocyanin-rich blueberries to benefit public health. However, it is widely agreed that the regular consumption of tasty, ripe blueberries can be unconditionally recommended.

Overall conclusion:  It can be safely stated that daily moderate intake (50 mg anthocyanins, one-third cup of blueberries) can mitigate the risk of diseases and conditions of major socioeconomic importance in the Western world.

Funding: The United States Highbush Blueberry Council (USHBC) offered support for this article by providing an honorarium to each author but had no role in the design and conduct of the review.  Author disclosures: AC, LRH, RZ-R, no conflicts of interest. AC acts as an advisor to the USHBC grant committee and has received research support from the USHBC. RK, WK, AJS, and FT have received research funding from the USHBC and have no conflict of interest.

Comment:  This is a literature review.  The USHBC paid the authors to write it.  That makes this article a paid advertisement for blueberries.  Why the authors think they have no conflict of interest in taking the money to write this is beyond me.  We can ask why the USHBC thinks this kind of “study” is needed.  Of course blueberries are recommended.  They are a fruit and all fruits are recommended.  The USHBC wants you to think that blueberries are especially beneficial, but that can be said of any fruit.  Not all fruits have sponsors paying for articles, however.

JOURNALS OF GERONTOLOGY: SPECIAL SECTION: AGING AND BLUEBERRIES (thanks to Bradley Flansbaum for sending)

The papers in this series were supported in one way or another by one or another blueberry trade associations.

• Blue Versus Gray: Potential Health Benefits of Blueberries for Successful Aging.  Donald K Ingram, PhD.  The Journals of Gerontology: Series A, Volume 74, Issue 7, July 2019, Pages 965–966. Sponsored by the Wild Blueberry Association of North America.
• Circulating Anthocyanin Metabolites Mediate Vascular Benefits of Blueberries: Insights From Randomized Controlled Trials, Metabolomics, and Nutrigenomics :  Ana Rodriguez-Mateos, et al.  The Journals of Gerontology: Series A, Volume 74, Issue 7, July 2019, Pages 967–976. This work was supported by the Medical Research Committee of the University of Düsseldorf (9772574) and by an unrestricted grant from the Wild Blueberry Association of North America. ARM and CH have received unrestricted research grants from the Wild Blueberry Association of North America. The other authors declare no conflicts of interests.
• Blueberries Improve Neuroinflammation and Cognition differentially Depending on Individual Cognitive baseline Status.  Barbara Shukitt-Hale, et al. The Journals of Gerontology: Series A, Volume 74, Issue 7, July 2019, Pages 977–983.  This research was supported by USDA Intramural funds. The blueberry powder used in this study was provided at no cost under a Material Transfer Agreement between the USDA and the U.S. Highbush Blueberry Council (USHBC). 
• Systematic Review of the Effects of Blueberry on Cognitive Performance as We Age .  Sabine Hein, et al. The Journals of Gerontology: Series A, Volume 74, Issue 7, July 2019, Pages 984–995.This work was supported by an unrestricted grant from the Wild Blueberry Association of North America.
• Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study  Julien Bensalem, et al. The Journals of Gerontology: Series A, Volume 74, Issue 7, July 2019, Pages 996–1007.  This work is part of the Neurophenols project. The specific aims of the program are to characterize and formulate fruit extracts from grape and blueberry and to evaluate their safety and efficacy in pre-clinical and clinical trials. Neurophenols Industry partners, some of which sell ingredients derived from grapes and blueberries, are listed here.

Comment: The introductory paper in this series explains what it is about: “The epidemiological evidence is strong and convincing regarding the health benefits of a diet rich in fruits and vegetables to ward off age-related diseases. However, what about individual foods?”  What about them?  I love blueberries but are they really better for older adults than raspberries, strawberries, or peaches, for that matter?  Variety is still a basic principle of nutrition.  Enjoy your fruit bowl.

A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia.  Blom AM, et al.  European Journal of Nutrition.  2019;58(4):1615–1624.

Purpose: “to investigate the triglyceride (TG) and LDL-cholesterol (LDL-C) lowering effects of a spread [i.e., margarine] with added plant sterols (PS) and fish oil as compared to a placebo spread.”

Conclusions: “Four-week consumption of the intervention spread led to significant and clinically relevant decreases in serum TG, LDL-C and other blood lipid concentrations.”

Funder: The study was funded by Unilever BCS Research and Development Vlaardingen, the Netherlands.

Conflicts of interest: of the authors, four are employed by Unilever.

Comment: Unilever makes margarines with plant sterols and fish oils.  You might buy them if they control blood lipid risk factors for heart disease.  This is in-house company research aimed at proving the benefits of a Unilever product, which is what so many other companies do.

But Unilever was one of the few Big Food companies that sponsored basic research (and maybe it still does?).  As I describe in my book, Unsavory Truth, Unilever was the sponsor of the basic research that demonstrated the harmful effects of trans-fat on disease risk.

I spotted some tweets about this study from Washington Post writer Tamar Haspel, who has a sharp eye for this sort of thing.  Her first tweet said:

Her second tweet explained the problem:

So of course I had to look up the study.  It’s not one I would ordinarily have noticed because its title does not use the word “probiotic,” which typically refers to the live bacteria (in yogurt, for example).  The evidence for benefits of probiotics is iffy, so this study raises lots of questions.

Let’s take a look at it:

The Study:  Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Depommier C, et al.  Nature Medicine (2019) Letter | Published: 01 July 2019.

Conclusion: I’ve left out the statistics to make this easier to read:  “Compared to placebo, pasteurized A. muciniphila improved insulin sensitivity…, and reduced insulinemia…and plasma total cholesterol…. Pasteurized A. muciniphila supplementation slightly decreased body weight…compared to the placebo group, and fat mass…and hip circumference…compared to baseline….In conclusion, this proof-of-concept study…shows that the intervention was safe and well tolerated and that supplementation with A. muciniphila improves several metabolic parameters.”

Competing interests:  Five of the authors “are inventors of patent applications…filed with [patent offices in at least 12 countries]…dealing with the use of A. muciniphila and its components in the context of obesity and related disorders.” Two of the authors are cofounders of A-Mansia Biotech S.A., a Belgian company that sells A. muciniphila supplements, presumably as weight-loss supplements.

Comment: As Haspel points out, the subjects in this study were given either (a) live bacteria, (b) Pasteurized (and, therefore, mostly dead) bacteria, or (c) a placebo.  The Pasteurized ones were associated with metabolic benefits and weight loss.  Pasteurization is what gets done to milk to kill most—not all—of the living bacteria it contains.  In this study, Pasteurized bacteria had the same effect on the microbiome as the unpasteurized.  The point of the study was to show that the Pasteurized supplement would induce weight loss; the observed loss, however, was not statistically significant.   Nature Medicine‘s editors should know better.  So should the New York Times’ editors.  Haspel points out that the New York Times account of the study accepted its conclusion uncritically, headlining it “A Probiotic for Obesity?”  At least the headline included a question mark.  The article did not mention the authors’ patents or conflicts of interest; it should have.

Bottom line: If you want to keep your microbiome healthy, eat a healthy diet.

The study: Using the Avocado to Test the Satiety Effects of a Fat-Fiber Combination in Place of Carbohydrate Energy in a Breakfast Meal in Overweight and Obese Men and Women: A Randomized Clinical Trial.  Zhu L, et al.  Nutrients 2019, 11, 952; doi:10.3390/nu11050952.

Conclusions: Replacing carbohydrates in a high-carbohydrate meal with avocado-derived fat-fiber combination increased feelings of satiety mediated primarily by PYY [peptide YY] vs. insulin. These findings may have important implications for addressing appetite management and metabolic concerns.

Funding: This research was supported by the Hass Avocado Board, Irvine, CA, USA.

Comment: Why does the Hass Avocado Board fund studies like this?  Because it generates headlines like this one: “Study finds avocados curb appetite and help with weight loss.”

Oops.  This is not what the study actually found.  As I learned from Obesity and Energetics Offerings (an exceptionally useful weekly compendium of articles having to do with energy balance), the discrepancy between what the study’s findings and what got reported merited its inclusion in OEO’s “Headline vs. Study” category.

• Headline: Study finds avocados curb appetite and help with weight loss.
• Study: This was a 6-hour RCT [randomized clinical trial] demonstrating effects on short-term reports of hunger – neither effects on actual food intake nor on body weight were studied.

Sponsored research is often about headlines, not science.

It’s also about advertising.  Here’s an ad that the Hass Avocado people sent out to all members of the Academy of Nutrition and Dietetics.  Although the Academy noted this was an advertisement, here’s what it looked like (thanks to my colleague Lisa Sasson for sending):

I love avocados but wish the Hass people would stick with how delicious they are and fund research on something more useful, like resistance to pests or climate change, maybe.

No such luck.  Here’s the request for proposals I just received:

Replacing Saturated Fat With Walnuts or Vegetable Oils Improves Central Blood Pressure and Serum Lipids in Adults at Risk for Cardiovascular Disease: A Randomized Controlled‐Feeding Trial.  Alyssa M. Tindall, et al. Journal of the American Heart Association. 2019;8:May 7, 2019.

Conclusions: “Replacing saturated fatty acids (FAs) with 57 to 99 g/d of walnuts for 6 weeks reduced central diastolic blood pressure compared with a diet similarly low in saturated FAs but with lower α‐linolenic acid content…This study represents a feasible food‐based approach for replacing saturated FAs with unsaturated FAs (including α‐linolenic acid) from walnuts and vegetable oils, demonstrating that relatively small dietary changes can reduce cardiovascular risk.

Funding: This study was funded by the California Walnut Commission…The California Walnut Commission provided funds for the research conducted. The commission’s staff was not involved with any aspects of conducting the study, analyzing the data, or interpreting the results reported in this article.

Comment: Walnuts, like pretty much all other nuts and seeds, contain healthy fats and other nutrients.  When substituted for unhealthier foods, they would be expected to demonstrate improvements.  This study contributes no new information and there is only one reason to do it: marketing (as I discuss in Unsavory Truth).  The California Walnut Commission wants you to eat more walnuts.  Trade associations or producers of pecans, macadamia nuts. pistachios, almonds, peanuts, hazelnuts, and any other nut you can think of have the same goal.  Do they all have to do this kind of research?  Apparently so.

Mixed nuts, anyone?

You may think, as I do, that everyone would be better off eating less sugar, but that’s not how The Sugar Association sees it.  This trade association for sugar producers funds research to demonstrate that eating sugar is a good thing and not harmful.

Here’s what The Sugar Association says:

The Sugar Association is committed to transparent engagement with researchers, external partners and consumers to address knowledge gaps and support independent, peer-reviewed science. Recent literature suggests this framework, rooted in transparency and communication and reflected in our Operating Principles, leads to increased public confidence in industry-funded research,* a goal the organization is working to achieve.

The asterisk refers to Achieving a transparent, actionable framework for public-private partnerships for food and nutrition research, a consensus report written by, among others, representatives of the International Life Sciences Institute, a well known front group for the food industry, and other organizations with ties to food companies.

The Sugar Association lists some of its recent publications [you can’t make this stuff up]:

• Bakke AJ, Stubbs CA, McDowell EH, Moding KJ, Johnson SL, Hayes JE. Mary Poppins was right: Adding small amounts of sugar or salt reduces the bitterness of vegetables. Appetite. 2018. doi: 10.1016/j.appet.2018.03.015. [Mary Poppins was talking about medicine, not vegetables: “Just a spoonful of sugar helps the medicine go down, In a most delightful way.”]
• Bailey RL, Fulgoni VL, Cowan AE, Gaine PC. Sources of Added Sugars in Young Children, Adolescents, and Adults with Low and High Intakes of Added Sugars. Nutrients. 2018;10(1):102.

Nutrition Today Supplement: Sweet Taste Perception and Feeding Toddlers. March/April 2017 – Volume 52 [The Sugar Association funded the conference that resulted in this supplement, which it also funded].

• Dwyer JT. Good Nutrition in Toddlers. Nutrition Today. 2017;52(2):S1-S2.5.
• Bailey RL, Barr SI. Introduction: Sweet Taste Perception and Feeding Toddlers. Nutrition Today. 2017;52(2):S3-S5.
• Achterberg C. A Perspective: Toddler Feeding, Science, and Nutrition Policy. Nutrition Today. 2017;52(2):S6-S13.
• Kleinman RE, Greer F, Cowart BJ, et al. Roundtable Proceedings: The Role of Innate Sweet Taste Perception in Supporting a Nutrient-Dense Diet for Toddlers, 12 to 24 Months Old. Nutrition Today. 2017;52(2):S14-S24. [Kleinman is co-chair of the 2020 Dietary Guidelines Advisory Committee]
• Murray RD. Influences on the Initial Dietary Pattern Among Children From Birth to 24 Months. Nutrition Today. 2017;52(2):S25-S29.Johnson SL, Hayes JE. Developmental Readiness, Caregiver and Child Feeding Behaviors, and Sensory Science as a Framework for Feeding Young Children. Nutrition Today. 2017;52(2):S30-S40.
• Hayes JE, Johnson SL. Sensory Aspects of Bitter and Sweet Tastes During Early Childhood.Nutrition Today. 2017;52(2):S41-S51.
• Moshfegh AJ, Rhodes DG, Goldman JD, Clemens JC. Characterizing the Dietary Landscape of Children, 12 to 35 Months Old. Nutrition Today. 2017;52(2):S52-S59.
• Welsh JA, Figueroa J. Intake of Added Sugars During the Early Toddler Period. Nutrition Today. 2017;52(2):S60-68.
• Palmer CA. Oral and Dental Health Considerations in Feeding Toddlers. Nutrition Today. 2017;52(2):S69-S75.