The industry newsletter, NutraIngredients.com, regularly posts Special Editions on Probiotics, meaning collections of its articles on the topic.  These promote the benefits—to digestion and many other physiological and mental aspects—of eating healthy bacteria.   But do probiotics really work?  And could they actually be harmful?  See comments below these selected articles.

• • Baby faeces’ ‘good bacteria’ a solid basis for disease-tackling probiotic supplement: ‘Good bacteria’ found in infant faeces could form the basis of a probiotic supplement that could help lower disease risk as researchers point to babies’ good health and absence of age-related diseases as good starting points… Read 
  • Survival of the fittest: Gut colonisation study could lead to gene-targeting probiotics: New probiotic products targeting individual genes for gut microbial diversity could be on the horizon after researchers outline a data-based approach that identifies the growth of beneficial microbes… Read 
  • Use of probiotics linked to brain sluggishness and stomach bloating: Study:  The use of probiotics could lead to a build-up of bacteria in the gut causing brain fogginess, US researchers conclude, as they also note its use is linked to bloating of the stomach… Read
  • No BBC, probiotics are not ‘quite useless’: A new BBC article dismisses the benefits of probiotics because a study failed to find colonization. It is a serious mistake to confuse colonization with efficacy and we need to get this message across to consumers… Read  
  • Delivery systems a ‘determining factor’ in probiotic success, suggests Lumina Intelligence: Delivery systems for probiotic supplements will determine probiotic storage, release time and viability through the body, according to recent research with these systems’ ability largely determining product success… Read  
  • Prebiotics as a concept still not well understood by many consumers, experts say: Research done by the Global Prebiotic Association shows that prebiotics as a concept is gaining traction with dedicated supplement users but has a long way to go to gain mainstream acceptance… Read
  • Focus on functional sports benefits seen as growing opportunity within microbiome research: Research in the effects of exercise on the microbiome has boosted not just a recent startup, but will fuel a growing category within the wider field of probiotics, an expert says… Read
  • Why PepsiCo, Coca-cola are betting on functional food and beverage brands: Legacy CPG companies PepsiCo and Coca-Cola have each snapped up or invested heavily in a functional food and beverage brand this year… Read
  • Highlights from the Harvard Probiotics Symposium: The recent Harvard Probiotics Symposium brought together scientific experts from across the globe to discuss: “Gut Health, Microbiota & Probiotics Throughout the Lifespan: Dietary Influences”. Here’s what we learned… Read
  • Prebiotic combination shows metabolic benefits for adults with acne: Pilot data: A combination of fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) prebiotics may improve glycemic and lipid metabolic measures in women with acne, suggests a small study from Italy… Read

Two recent articles in Cell raise questions about the benefits of probiotics.

• Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features: Probiotics transiently colonize the human gut mucosa in highly individualized patterns, thereby differentially impacting the indigenous microbiome and host gene-expression profile, a trait which is predictable by baseline host and microbiome features, but not by stool shedding.
• Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT: Probiotics perturb rather than aid in microbiota recovery back to baseline after antibiotic treatment in humans.

In translation:

• The murine [mouse] & human gut mucosal microbiome only partially correlates with stool
• Mice feature an indigenous-microbiome driven colonization resistance to probiotics
• Humans feature a person-specific gut mucosal colonization resistance to probiotics
• Probiotic colonization is predictable by pre-treatment microbiome & host features

In further translation:

• Not everyone responds to probiotics, which means that they may be worth a try and you may get lucky.

And an even more recent article in JAMA Internal Medicine questions whether probiotics might be harmful.  It warns about:

• The safety of bacteria in probiotic supplements has not been fully established.
• They can lead to infections and allergic reactions.
• Probiotic supplements often do not meet manufacturing standards (identity, purity, strength, composition).
• Introduction of new genes for antibiotic resistance into microbiomes.

The article concludes:

Consumers and physicians should not assume that the label on probiotic supplements provides adequate information to determine if consuming the live microorganism is worth the risk.

What to think about all this?  If you like yogurt, enjoy!  But supplements are another matter.

President Trump has just announced a truce in our trade war with China.  We need one.

In August, the Trump Administration said it would provide $12 billion to farmers to make up for the losses in income caused by the dispute.

I’ve been collecting items about what’s actually happening with the bailout payments.

• Not much has been paid out: The New York Times reports that the USDA has paid out just $838 million of the $6 billion that became available in September. Another pool of up to $6 billion is expected to become available next month.
• They are not helping Wisconsin dairy farmers: According to the Milwaukee Sentinal Journal, about 4,800 dairy farms are collectively getting about 80 percent of the $10.4 million coming to the state, with an average payment of $2,390.  But the Wisconsin Farmers Union says a 55-cow dairy farm would receive a one-time payment of $725 from the Trump bailout program, but would lose between $36,000 and $48,000 this year due to low milk prices.
• They are not doing much for Iowa farmers either:  According to the Des Moines Register, the 4300 payments total nearly $31 million, with an average payment of $7,236.  But 100 payments are less than $25, 24 are less than $10, and 11 are $5 or less.
• Payments are going to 1,100 city residents; these average $881.  According to the Environmental Working Group, the recipients may or may not actually be involved in farming.  The EWG got the data from the USDA.
• The National Corn Growers Association wants more money for corn farmers.  Its letter to USDA says the agency does not understand the how badly the trade disruptions are affecting its members. Its own study estimates corn growers losses at $6.3 billion.
• North Dakota soybean growers have a storage problem, says the New York Times,  because they can’t sell the beans to China.
• Kansas soybean farmers are also in trouble, writes the New York Times.
• Overall farm income is declining, says USDA.

I think it’s fair to conclude at this point that current trade policies are tough on US agribusiness.

The endless arguments about dietary fats and dietary fat versus carbohydrate make no sense to me, because we mostly eat these as components of food, and foods as components of diets of massive complexity.

But scientists do like to debate such issues so it comes as a breath of fresh air to read a consensus statement from people who do not necessarily agree about such issues.

Looks good to me.  I’m glad they did this.

Since publication of my latest book, Unsavory Truth: How Food Companies Skew the Science of What We Eat, I’ve been collecting particularly delicious examples.

Here’s one I discovered through a tweet:

I looked up the press release.

Montmorency tart cherries may have the potential to improve exercise recovery in active females, suggests a new study published in the European Journal of Sport Science.

Researchers in the U.K. found that Montmorency tart cherry concentrate, when consumed twice a day for eight days, reduced self-reported muscle soreness and impacted certain aspects of muscle function after exercise, compared to a placebo.

Guess who funded this?Another example of a study with a sponsor predictable from its title, alas.

David Katz.  The Truth About Food: Why Pandas Eat Bamboo and People Get Bamboozled.  Independently Published, 2018.

I greatly admire David Katz for his courage to say what he thinks in his weekly blog posts, such as this one defending nutrition science against recent attacks:

The contention that we are clueless about diet and health, that all measures are bereft, all knowledge suspect, all research questions however seemingly inane admissible- is the rubbish it seems. It is a pop culture myth…The entire nutrition narrative has been hijacked so that:

A)  Silly (I’m being kind) questions are posed and tested

B)  Uninformative, conflicting, confusing, contrarian answers ensue

C)   Great academics and intellectuals, generally of the sort that opines from some lofty sacred perch but who doesn’t actually DO nutrition research, or clinical care, or much of anything of practical value to the world- swoop in to tell us how hopelessly shabby the field and overall state of our understanding are

D)  The media propagate all of the above

E)   Massive pseudo-confusion prevails

That leaves just one important question as yet unanswered: why?

That answer is obvious. Profit.

If only he didn’t write at such length to get to that point—this new book is 752 pages, a doorstop.  It is, as far as I can tell, a compendium of his published articles in Huffington Post and other places, organized into two main sections of three chapters each: Lies (Lies, Statistics, and Damned Lies) and Truth (The Truth, Nothing but the Truth, and The Whole Truth).

The Lies section deals with nutrition science.  You can recognize lies about nutrition science, says Katz, because they are

• Generally supremely certain, leaving no room for doubt or challenge
• Generally revolutionary, intended to replace all that was known before until they, in turn, are replaced by newer lies.

In contrast, truth is

• Generally very modest, leaving ample room for doubts about details
• Generally evolutionary, intended to add to and modify all that was known before.

Much of the book expands on those concepts.  Reading the Lies section will teach you a lot about how science works in theory and practice.  The Truth section will teach you a lot about nutrition.

With that said, I wish this book had been edited, and firmly.  It reads as if the online articles were simply reprinted as they appeared online, but with references added (the underlining of the former hyperlinks remains).

The Table of Contents lists just the six main chapters, but chapter 1 is more than 200 pages long.  The list of Lies is given on page 42 but it’s hard to know what they cover, as they are organized by fallacy (e.g., false equivalence fallacy, ripple-free pond fallacy).

The topics covered in Truths are listed on pages 311-313; these cover matters you might want to know about such as cholesterol, cooking oils, lectins, and Paleo diet, in alphabetical order.

I mention these organizational details because—and I can scarcely believe it—this 752-page book has no index.

If you want to find Katz’s well-worth-reading thoughts on specific nutrition studies or commentaries on nutrition science (the Lies), you are out of luck.  You might be able to guess that his critique of Gwyneth Paltrow’s nutrition advice can be found under what he calls the “celebrity equals expertise fallacy,” but if you want to read his analysis of research on low-carb diets, for example, you will have to read through a lot to find it. This is a shame, because his analyses are often spot-on.

The proceeds from this book go to the True Health Initiative, a nonprofit that Katz founded and now heads.

The food industry is intensely interested in personalized nutrition because it can create and sell products appeared to be aimed directly at individual lifestyles and preferences.

This approach is aimed much more at marketing than it is about public health.

With that said, take a look at how the food industry is using this idea.

Special Edition: Personalized Nutrition

The future is personal, but the revolution is already taking place around us. Innovative science is combining with entrepreneurial endeavor to bring personalized nutrition to our fingertips.

Personalized nutrition is breaking down the silos and bringing together experts in genetics and genomic profiling, microbiology, nutrition and diet, mobile technology, big data, healthcare and more.

In this special edition we talk to the pioneers and experts in this sector, the scientists and the emerging brands, and the tech developers bringing the personalized nutrition future to the present day.

• Personalized nutrition approaches helping to drive evolution of supplement retailing: Personalized nutrition is being folded into the ongoing evolution of retailing in the dietary supplement space, market experts say… Read
• Research backs personalized nutrition process, even if data on customized products lacks, expert says: While personalized nutrition proponents like to push the benefits of the approach, there is little research that backs the notion that products customized for individual consumers lead to better health outcomes than do more generic formulas. But that misses the point, said one expert… Read
• Persona CEO: ‘Chase the shiny new technology that has a big price tag – that’s not always the best solution’: Is a lifestyle questionnaire ‘personal’ enough for personalized nutrition? Persona’s founder and CEO Jason Brown talks about growing a business in the personalized nutrition space.. Read
• Personalized nutrition ‘milestone’: InsideTracker data validates algorithmic platform to improve wellness: Data from 1,033 generally healthy individuals using InsideTracker shows that the automated, web-based personalized nutrition platform is capable of normalizing serum biomarker levels in healthy subjects… Read
• Food selfies and data: Nutrino wants to make personalized nutrition easier for users:A mathematician and an engineer bootstrapped a nutrition-tech company about seven years ago. Their goal was to create a platform that documents the diverse ways human bodies extract nutrition from food… Read
• ‘Hyper-personalised’ recommendations: Spoon Guru targets global domination with growing list of partnerships:UK food tech start-up Spoon Guru has a goal of becoming the dominant technology platform for users looking for product recommendations based on specific lifestyle goals or dietary needs, says co-founder and CEO Markus Stripf, as the company looks to increase its partners globally and launch in the USA… Read
• Nordic Group: Nutrigenomics needs to be ‘done with integrity’ – it’s too early for direct consumer models: Nutrigenomics is gaining plenty of attention but it remains extremely complex and unadapted to direct-to-consumer models, says the MD of Nordic Group – owner of DNA Life and more recently AthGene… Read
• Lux Research: ‘It’s paramount that microbiome data is used for personalized nutrition’: A new market research report explores how the personalized nutrition space can elevate itself beyond “just recommending diets” and become an integral part of preventive health care… Read
• Weight loss presents ‘lucrative’ opportunity in nutrigenomics, says analyst: Nutrigenomics remains a growing niche within the burgeoning personalised nutrition trend but there is significant potential to spark mass market appeal with a focus on weight loss, says a consumer expert… Read

The US Global Change Research Program released its 4th report on climate change Wednesday night, coincidentally or deliberately during the slow news Thanksgiving holiday.

The U.S. Global Change Research Program (USGCRP) is a Federal program mandated by Congress to coordinate Federal research and investments in understanding the forces shaping the global environment, both human and natural, and their impacts on society.

USGCRP comprises 13 Federal agencies that conduct or use research on global change and its impacts on society, in support of the Nation’s response to global change.

The report comes in two volumes, a technical report and an assessment report.

Don’t look for any good news here, especially for agriculture.

U.S. agriculture and the communities it supports are threatened by increases in temperatures, drought, heavy precipitation events, and wildfire on rangelands (Figure 1.10) (Ch. 10: Ag & Rural, KM 1 and 2, Case Study “Groundwater Depletion in the Ogallala Aquifer Region”; Ch. 23: S. Great Plains, KM 1, Case Study “The Edwards Aquifer”). Yields of major U.S. crops (such as corn, soybeans, wheat, rice, sorghum, and cotton) are expected to decline over this century as a consequence of increases in temperatures and possibly changes in water availability and disease and pest outbreaks (Ch. 10: Ag & Rural, KM 1). Increases in growing season temperatures in the Midwest are projected to be the largest contributing factor to declines in U.S. agricultural productivity (Ch. 21: Midwest, KM 1). Climate change is also expected to lead to large-scale shifts in the availability and prices of many agricultural products across the world, with corresponding impacts on U.S. agricultural producers and the U.S. economy (Ch. 16: International, KM 1).

Chapter 10 has four key messages, none of them cheerful:

1:  REDUCED AGRICULTURAL PRODUCTIVITY: Food and forage production will decline in regions experiencing increased frequency and duration of drought. Shifting precipitation patterns, when associated with high temperatures, will intensify wildfires that reduce forage on rangelands, accelerate the depletion of water supplies for irrigation, and expand the distribution and incidence of pests and diseases for crops and livestock. Modern breeding approaches and the use of novel genes from crop wild relatives are being employed to develop higher-yielding, stress-tolerant crops.

2: DEGRADATION OF SOIL AND WATER RESOURCES: The degradation of critical soil and water resources will expand as extreme precipitation events increase across our agricultural landscape. Sustainable crop production is threatened by excessive runoff, leaching, and flooding, which results in soil erosion, degraded water quality in lakes and streams, and damage to rural community infrastructure. Management practices to restore soil structure and the hydrologic function of landscapes are essential for improving resilience to these challenges.

3.  HEALTH CHALLENGES TO RURAL POPULATIONS AND LIVESTOCK: Challenges to human and livestock health are growing due to the increased frequency and intensity of high temperature extremes. Extreme heat conditions contribute to heat exhaustion, heatstroke, and heart attacks in humans. Heat stress in livestock results in large economic losses for producers. Expanded health services in rural areas, heat-tolerant livestock, and improved design of confined animal housing are all important advances to minimize these challenges.

4: VULNERABILITY AND ADAPTIVE CAPACITY OF RURAL COMMUNITIES: Residents in rural communities often have limited capacity to respond to climate change impacts, due to poverty and limitations in community resources. Communication, transportation, water, and sanitary infrastructure are vulnerable to disruption from climate stressors. Achieving social resilience to these challenges would require increases in local capacity to make adaptive improvements in shared community resources.

The recommendations: reduce greenhouse gas emissions, now.

My colleagues who attended the Academy of Nutrition and Dietetics annual meeting and Expo brought back examples of what I love to call dietetic junk foods.

The big trends in such products are gluten-free and allergy-free—apparently without much regard for taste (at least by my standards).

Here is an example of a gluten-free product: 

Check the ingredient list:

Cane sugar, pea starch, potato starch,non-hydrogenated shortening (palm oil, modified palm oil), white rice flour, tapioca starch, water, tapioca syrup, pea protein, salt, pea fiber, natural flavor, modified cellulose, inulin, sodium bicarbonate, sunflower lecithin, beta-carotene (color).

And, in case you were worried, it’s “not a product of genetic engineering.”

To me they taste like chalk, but sweet.

Here’s an example of an allergy-free product:

It too has a long ingredient list:

Organic rolled oats, rice protein crisps (rice protein, rice starch), tapioca syrup, cocoa butter, pearled sorghum crisps, organic caramel (organic cane sugar, water), date paste, brown sugar, dried banana, roasted and salted sunflower seeds (sunflower kernels, sunflower oil, salt) safflower oil, white pearled sorghum flour, popped sorghum.

But this one is remarkable for what it does not contain:

I did not particularly like the texture or taste (off flavors) of this one.

Apparently, the Expo had loads of these.

Why?  Real (relatively unprocessed) foods are less profitable, alas.