Currently browsing posts about: Sponsored-research

This one was sent to me by a reader: Animal vs. Plant Protein: New Research Suggests That These Protein Sources Are Not Nutritionally Equivalent: Scientists found that two-ounce-equivalents (oz-eq) of animal-based protein foods provide greater essential amino acids (EAA) bioavailability than the same quantity of plant-based protein foods. The study challenges the Dietary Guidelines for Americans (DGAs) which suggest these protein sources are nutritionally equivalent.

I went right to the study: “Effects of Consuming Ounce-Equivalent Portions of Animal- vs. Plant-Based Protein Foods, as Defined by the Dietary Guidelines for Americans on Essential Amino Acids Bioavailability in Young and Older Adults: Two Cross-Over Randomized Controlled Trials” by Gavin Connolly, Joshua L. Hudson, Robert E. Bergia, Eric M. Davis, Austin S. Hartman, Wenbin Zhu, Chad C. Carroll and Wayne W. Campbell, 25 June 2023, Nutrients. DOI: 10.3390/nu15132870

Oh.  It’s in Nutrients, a journal that might as well be called “The Journal of Industry-Funded Research” (authors have to pay for publication of their articles in this journal–2900 Swiss Francs).

The study was designed to demonstrate that protein from animal sources is better than protein from plant sources, immediately raising the question: Who sponsored this study?

Funding: This research was funded by the Pork Checkoff and the American Egg Board—Egg Nutrition Center. The supporting sources had no role in study design; collection, analysis, and interpretation of data; writing of the report; or submission of the report for publication.

Do the authors report conflicts of interest?  Yes, they do:

Conflicts of Interets: When this research was conducted, W.W.C. received research funding from the following organizations: American Egg Board’s Egg Nutrition Center, Beef Checkoff, Pork Checkoff, North Dakota Beef Commission, Barilla Group, Mushroom Council, and the National Chicken Council. C.C.C. received funding from the Beef Checkoff. R.E.B. is currently employed by Archer-Daniels-Midland (ADM); the research presented in this article was conducted in a former role and has no connection with ADM. G.C., J.L.H., E.M.D., A.S.H. and W.Z. declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

I’m not going to bother going through the methods, results, or other details.  The point here is that industry-funded research has a high probability of producing results favorable to the sponsors’ interests, as happened in this instance.  The statement that the sponsors had no role may or may not be true; it’s hard to know without further investigation, but research on this question demonstrates that the statement is not always accurate.  Funding exerts influence, whether recognized by researchers or not.

A reader who wishes to remain anonymous forwarded this email she received from Kristen Hicks-Roof PhD, RDN, LDN, FAND , Director of Human Nutrition·National Pork Board.

Growing Strong: Animal-Source Foods’ Role in Childhood Development and Sustainable Food Systems

Childhood and adolescence are critically important periods for growth and development. These periods are also key for establishing healthy dietary patterns that can influence eating behaviors and health into adulthood.

During these stages, animal-source foods provide critical nutrients — such as high-quality protein, iron, zinc, choline, and B vitamins — that are not easily replaced from other sources.

In this webinar, Dr. Adegbola Adesogan will:

– Present evidence on the role of animal-source foods in childhood development and impact on future health outcomes

– Review how animal-source foods are a source of key nutrients that support health in children and adolescents

The CPE activity application for this webinar is pending review by the Commission on Dietetic Registration (CDR) and approval for 1.0 CPEU.

Comment

Presumably, the CDR will approve this for continuing education credits required for dietetic licensing.  Also presumably, participants will not learn about the polluting effects of Pork CAFOs or the community lawsuits against them for obnoxious odors and other offenses.  Or the way the pork industry fights back against such complaints.  Or the welfare issues about farrowing crates.  Or complaints about Pork Checkoff programs.

As I’ve noted previously, dietitians are able to fulfill all requirements for continuing education credits from industry-funded courses like this one.

Conflict of interest, anyone?

The title of this article triggered my usual question: Who paid for this?  I cannot think of any reason other than marketing this supplement for doing a study like this.

Multi-nutrient supplementation of astaxanthin, vitamin E and grape juice improves episodic memory, cognitive performance – RCT:  A study has found that 12 weeks of multi-nutrient supplementation, comprising astaxanthin, vitamin E and grape juice extract, resulted in improved episodic memory and several biomarkers associated with cognitive health…. Read more

The study: Lopresti AL, Smith SJ, Riggs ML, Major RA, Gibb TG, Wood SM, Hester SN, Knaggs HE. An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024; 16(11):1770. https://doi.org/10.3390/nu16111770

Method: adults aged 40 to 70 years with subjective memory complaints were randomized to take a supplement containing vitamin E, astaxanthin, and grape juice extract daily for 12 weeks or a matching placebo.

Outcomes:  Changes in cognitive tasks assessing episodic memory, working memory, and verbal memory., speed of information processing, attention, and self-report measures of memory, stress, and eye and skin health.

Results: “Compared to the placebo, nutritional supplementation was associated with larger improvements in one primary outcome measure comprising episodic memory (p = 0.037), but not for working memory (p = 0.418) or verbal learning (p = 0.841). Findings from secondary and exploratory outcomes demonstrated that the nutraceutical intake was associated with larger improvements in the Everyday Memory Questionnaire (p = 0.022), increased plasma brain-derived neurotrophic factor (p = 0.030), decreased plasma malondialdehyde (p = 0.040), and increased skin carotenoid concentrations (p = 0.006). However, there were no group differences in changes in the remaining outcome measures.”

Conclusions: “The results from this 12-week study provide some support for the cognitive-enhancing effects of a nutraceutical containing astaxanthin, vitamin E, and grape juice extract in adults with self-reported memory complaints. This was demonstrated by improvements in one primary outcome measure (episodic memory) but not working memory or verbal learning.”

I just ran across this one.  The Prune Study?  To prove that prunes prevent osteoporosis?  Who could possibly be paying for this?

The study: Koltun, K.J., Strock, N.C.A., Weaver, C. et al. Prunes preserve cortical density and estimated strength of the tibia in a 12-month randomized controlled trial in postmenopausal women: The Prune Study. Osteoporos Int 35, 863–875 (2024). https://doi.org/10.1007/s00198-024-07031-6

Method: “evaluate the effects of 50 g and 100 g of prunes vs. a Control group on vBMD, bone geometry, and estimated strength of the radius and tibia via peripheral quantitative computed tomography (pQCT) in postmenopausal women. Women (age 62.1 ± 5.0yrs) were randomized into Control (n = 78), 50 g Prune (n = 79), or 100 g Prune (n = 78) groups.”

Results: “The most notable effects were observed at the 14% diaphyseal tibia in the Pooled (50 g + 100 g) Prune group, in which group × time interactions were observed for cortical vBMD (p = 0.012) and estimated bone strength (SSI; p = 0.024); all of which decreased in the Control vs. no change in the Pooled Prune group from baseline to 12 months/post.”

Conclusion: “Prune consumption for 12 months preserved cortical bone structure and estimated bone strength at the weight-bearing tibia in postmenopausal women.”

Funding: “We thank the California Prune Board (Award Number: 180215) for the funding and prunes.”

Comment: The California Prune Board is working hard on this.  I’ve posted at least one previous study on the same theme.  I’ve read the Results several times and still am not getting what’s claimed versus ‘no change in the Pooled Prune group from baseline to 12 months/post.'”  But even if there is an effect, the question is: compared to what?  Do other dried fruits provide similar effects?  What about whole fruits?  This is a one-food study designed to produce results that can be used in marketing.  What’s going on here?

We Work Hand-in-Hand with California’s Prune Growers and Handlers

The California Prune Board (CPB) works to unite California’s diverse prune growers and handlers around activities that benefit the industry today and pave the way for its bright future. As we all know, California Prunes are the best in the world – and CPB serves the industry by helping to drive demand and premium value.

Doing a good job?  You decide.

The California Table Grape Commission funds lots of research for an explicit purpose: “to help discover how and why grapes are beneficial to health.”

It lengthy list of funded projects is here.  Published studies are here.

You want to do one of these studies?  Let them know here.

Grape research is conducted using a freeze-dried table grape powder, designed to facilitate reproducible data and to provide researchers with a grape sample that is available year-round. Additionally, a grape powder placebo is made available.

Comment: If you want funding, you need to design your study to show benefits.  The Commission is unlikely to risk funding proposals unlikely to show benefits.  [Thanks to David Michaels for sending this one].

And Charles Platkin sent me the press release for one of the Commission’s funded studies: Hu, W., Zheng, R., Feng, Y., Tan, D., Chung-Tsing, G.C., Su, X., and Kim, J.E. (2023). Impacts of regular consumption of grapes on macular pigment accumulation in Singapore older adults: a randomized, controlled trial. Food Funct. 14, 8321-8330. Doi: 10.1039/d3fo02105j.  The abstract is here.

Conclusions: Regular intake of grapes may improve eye health in Singapore older adults, specifically in augmenting MPOD, which can be explained by an increase in plasma total antioxidant capacity and phenolic content, and the downregulation of AGEs.

I’m all for eating grapes and every other fruit.  Does one kind of fruit have more substantial effects on health than any other?  The study did not compare grapes to any other fruit; it just looked at the benefits of grapes.

I’m guessing lots of other fruits will do the same.

The moral: eat a variety of fruits and vegetables.  And be skeptical about the importance of studies like this.

To stay in good standing as Registered Dietitian-Nutritionists, members of the Academy of Nutrition and Dietetics must complete a certain number of continuing education credits.  Here’s one way to get them (sent to me by a member who wishes to remain anonymous).

Here’s what they need to learn to earn them:Comment

Did participants learn about the cons of Splenda (and artificial sweeteners in general) as well as the pros?  One can only hope.

It’s been a couple of years since I’m commented on almond-industry research funding, but it remains hard at work.  Sasha Matera-Vatnick sent me a report of this study from Food Technology.  It essentially reproduced the California Almonds’ press release: New Research: Eating Almonds Can Aid in Post-Exercise Recovery.

The study: Witard, O., Siegel, L., Rooney, J., Marjoram, L., Mason, L., Bowles, E., Valente, T., Keulen, V., Helander, C., Rayo, V., Hong, M. Y., Liu, C., Hooshmand, S., & Kern, M. Chronic almond nut snacking alleviates perceived muscle soreness following downhill running but does not improve indices of cardiometabolic health in mildly overweight, middle-aged, adults. Frontiers in Nutrition. 2024 January 8: doi: https://doi.org/10.3389/fnut.2023.1298868

Method: 25 mildly overweight subject used a treadmill for 30 min after 8-weeks of consuming either 57 g/day of whole almonds (ALMOND) or an isocaloric amount (86 g/day) of unsalted pretzels (CONTROL).

I learned about this one from FoodNavigator-Europe.

Ashwagandha has ‘tremendous potential’ for promoting healthy aging: Review:  Ashwagandha could serve as a potent anti-aging ingredient by improving immune system function and acting as an antioxidant, according to a review published in Frontiers in Nutrition…. Read more

This is the kind of headline that makes me ask: “Who paid for this?”

FoodNavigator usually provides references, so I could easily look this one up.

The study: Current insights into transcriptional role(s) for the nutraceutical Withania somnifera in inflammation and aging.  Praful Saha, Saiprasad Ajgaonkar,  Dishant Maniar, Simran Sahare, , Dilip Mehta,  Sujit Nair. Front. Nutr., 03 May 2024. Volume 11 – 2024 | https://doi.org/10.3389/fnut.2024.1370951.

Conclusions: “Management of aging is difficult due to its progressive and irreversible nature, as well as the comorbidities associated with aging. However, the quality of biological aging can be improvised by recent advancements including intervention with nutraceuticals that can modulate the transcriptional activity of different genes implicated in aging and age-related complications…Taken together, given the modulation of key RNA markers in aging and inflammation pathways, there is tremendous potential for harnessing the beneficial effects of Withania for achieving healthy aging.”

Funding: “The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.”

Conflict of interest: “PS, SA, DMa, SS, DMe, and SN were employed by PhytoVeda Pvt. Ltd. and Viridis Biopharma Pvt. Ltd., Mumbai, India. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.”

Comment:  I looked up Viridis BioPharma.

Viridis BioPharma is a marketing, manufacturing and research company that deals with active ingredients for the pharmaceutical, nutraceuticals, food and cosmetic industries, medicated dressings and formulations to treat wounds, burns and other novel clinically proven topical formulations.  What drives us is the desire to extend lifespans and, more than that, to extend health and wellbeing at every stage of life.

Employees of this and the other company developed this quite comprehensive review.  The authors state its purpose explicitly.

WS [Withania somnifera] is known for its versatility in treating a range of conditions, such as immunomodulation, rejuvenation, enhancement of cognitive function, inflammation, enhancing concentration, etc. However, a synthetic review exploring its potential role in ameliorating aging and aging-related disorders is currently lacking…This may facilitate the development of various preventive and therapeutic strategies employing WS as a nutraceutical for healthy aging.

Their funding statement is accurate; they weren’t paid particularly to write this article; they are just on salary generally.  And they are members of the editorial board of this journal.  Oh dear.

Here’s what the NIH says about ashwagandha.  It finds some evidence for use but concludes “most studies have been conducted as part of a traditional medical system, so the potential effects of ashwagandha when used as a dietary supplement outside of that approach remain unclear.”