by Marion Nestle

Currently browsing posts about: Sponsored-research

Jun 7 2021

Industry-funded review of the week: Refined grains

The review:  Do Refined Grains Have a Place in a Healthy Dietary Pattern: Perspectives from an Expert Panel Consensus Meeting Yanni Papanikolaou, Joanne L Slavin, Roger Clemens, J Thomas Brenna, Dayle Hayes, Glenn A Gaesser, Victor L Fulgoni, III.  Current Developments in Nutrition, Volume 4, Issue 10, October 2020, nzaa125.

Method: “A scientific expert panel was convened to review published data since the release of 2015 dietary guidance in defined areas of grain research, which included nutrient intakes, diet quality, enrichment/fortification, and associations with weight-related outcomes.

Results: 

1) whole grains and refined grains can make meaningful nutrient contributions to dietary patterns,

2) whole and refined grain foods contribute nutrient density,

3) fortification and enrichment of grains remain vital in delivering nutrient adequacy in the American diet,

4) there is inconclusive scientific evidence that refined grain foods are linked to overweight and obesity, and

5) gaps exist in the scientific literature with regard to grain foods and health.

Supported by the Grain Foods Foundation.  The sponsors (Grain Foods Foundation) had no role in the design of the study or in the collection, analyses, or interpretation of the data.

Author disclosures: YP, as President of Nutritional Strategies, provides food, nutrition, and regulatory affairs consulting services for food and beverage companies and food-related associations and collaborates with VLF on NHANES analyses. VLF, as Senior Vice President of Nutrition Impact, provides food and nutrition consulting services for food and beverage companies. VLF also conducts analyses of NHANES data for members of the food industry. JLS, RC, JTB, DH, and GAG all received an honorarium and travel expenses in the current scientific collaboration.

Comment: The Grain Foods Foundation commissioned the panel and paid the panel participants for their service and travel.  For the authors, this was a paid gig.  The Foundation got what it paid for.  About results #1, 2, and 5, there can be no argument.  #1 and #2 are obvious and did not require a scientific panel to come to those conclusions: even refined grains have nutritional value, not least because they are fortified with several key nutrients.   That’s why these authors consider fortification and enrichment to be “vital.”

What this really is about is to demonstrat that refined grains are healthy and do no harm (#4).  But refined grains are major components of ultra-processed foods, which cause people who eat them to take in more calories than they recognize or need (see Hall et al, 2019) and are strongly associated with higher levels of obesity, chronic disease, and mortality.  Despite dozens of studies consistently linking ultra-processed foods to these conditions, this industry-sponsored panel says the evidence is inconclusive.

The underlying purpose of this study, therefore, is to cast doubt on the connection between refined grains, ultra-processed foods, and weight gain.

With independently funded research, even by biased researchers, the underlying purpose is usually explicit.

–Thanks to Lisa Young for alerting me to this one.

Jun 1 2021

Industry-funded study of the week: Mushrooms!

Method:  The investigators obtained data on the nutrient content of 84 grams of mushrooms and looked to see how consuming them might change typical dietary intake patterns.

Conclusion: “Addition of mushrooms to USDA Food Patterns increased several micronutrients including shortfall nutrients (such as potassium, vitamin D and choline), and had a minimal or no impact on overall calories, sodium or saturated fat.”

Funding: “The study and the writing of the manuscript were supported by the Mushroom Council.”

Conflict of interest : “SA as Principal of NutriScience LLC performs nutrition science consulting for various food and beverage companies and related entities; and VLF as Senior Vice President of Nutrition Impact, LLC performs consulting and database analyses for various food and beverage companies and related entities.”

Comment: As I keep saying, all fruits and vegetables have nutritional value.  Some have more of one nutrient than another.  A good dietary strategy is to vary them to meet needs for the nutrients they contain.   The only scientific purpose of this study is to demonstrate that mushrooms have nutrients.  I could have told them that.

This study is about marketing, not science.  It was conducted by a firm that specializes in industry-funded studies useful for marketing purposes.

May 24 2021

Industry-funded study of the week: Cultured meat

US and UK Consumer Adoption of Cultivated Meat: A Segmentation Study.  Keri Szejda, Christopher J. Bryant, Tessa UrbanovichFoods 2021, 10(5), 1050.

Background: “Despite growing evidence of the environmental and public health threats posed by today’s intensive animal production, consumers in the west remain largely attached to meat. Cultivated meat offers a way to grow meat directly from cells, circumventing these issues as well as the use of animals altogether.”

Purpose: “The aim of this study was to assess the overall consumer markets and a range of preferences around cultivated meat in the US and the UK relating to nomenclature, genetic modification, health enhancements, and other features.”

Conclusion: “there are solid consumer markets for cultivated meat in the UK and the US, despite an overall lack of familiarity with the product. Younger generations are the most open to trying cultivated meat, and government seals of approval are considered important. Consumers tend to prefer non-GM cultivated meat, and while nutritional enhancements do not add much to consumer appeal overall, they may be an effective way to provide tangible benefits to more skeptical consumers.”

Funding: “This work was supported by Aleph Farms. Aleph Farms participated in the study design, but not other aspects of the project.”

Conflicts of interest: “The authors report no conflicts of interest.”

Comment: Aleph Farms produces cell-based meat substitutes: “We’re paving a new way forward in the field of cultivated meat, growing delicious, real beef steaks from the cells of cows, eliminating the need for slaughtering animals or harming the environment.”

The company paid for consumer research to find out how to sell its product.   The authors perceive no conflicted interests in this kind of paid research.  The biases induced by paid research are often unconscious and unrecognized.  The result of this study is an implied suggestion to add nutrients to cell-based meat products as a means to convince people to buy them.

This is marketing research.

Thanks to Michele Simon for sending a query about this paper.

May 17 2021

Industry-funded study of the week: Soy foods

I recently received an email from the Soyfoods Council: “If You’re Confused About Endocrine Disruptors, Here’s Why Soy Isn’t One.”

The email explained that “the Soyfoods Council is a non-profit organization, created and funded by Iowa soybean farmers, providing a complete resource to increase awareness of soyfoods, educate and inform media, healthcare professionals, consumers and the retail and foodservice markets about the many benefits of soyfoods.  Iowa is the country’s number one grower of soybeans and is the Soyfoods Capital of the world.”

The email referred to a just-published paper

The Study: Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data, by Mark Messina,Sonia Blanco Mejia,Aedin Cassidy,Alison Duncan,Mindy Kurzer,Chisato Nagato, et al.  Critical Reviews in Food Science and Nutrition, published online: 27 Mar 2021.

Conclusion: After extensive [my emphasis] review, the evidence does not support classifying isoflavones as endocrine disruptors.

Funding: “Funds were provided by the Soy Nutrition Institute and the European Plant-based Food Association to MM and the Toronto 3D Knowledge Synthesis & Clinical Trials Foundation for work related to the development and writing of this paper.”

Disclosures: Mark John Messina receives funding from the Soy Nutrition Institute as its Executive Director. Both Mindy Kurzer and John Sievenpiper are on the advisory board of the Soy Nutrition Institute. Ian Rowland is on the advisory board of the European Plant-based Foods Association. I have disclosed those interests fully to Taylor & Francis, and have in place an approved plan for managing any potential conflicts arising from these positions.

Comment: “Extensive” is an understatement; the paper has 688 references.  This may be overkill, but its purpose is to put to rest any concerns that soybeans might act as endocrine disrupters and, therefore, should be avoided.  The Soy Foods Council, obviously, wants you to stop worrying about this and paid for this review for that purpose.

I’m not particularly worried about soybeans.  As I wrote in What to Eat, I view soy as neither poison nor panacea.  But there is plenty of evidence on both sides.  That’s why paid reviews are not helpful.

May 10 2021

Industry-funded study of the week: Walnuts and cognitive decline

The study: Investigating walnut consumption and cognitive trajectories in a representative sample of older US adults.  Nicholas J. Bishop and Krystle E. Zuniga.  Public Health Nutrition Volume 24 Issue 7 , May 2021 , pp. 1741 – 1752.

Purpose: To estimate the association between whole walnut intake and cognitive change in a sample of 3632 US adults aged 65 years and older.

Method:  This was a secondary analysis of dietary data and health outcome from the Health and Retirement Study and Health Care and Nutrition Study.

Conclusions: “We identified an association between walnut consumption and cognitive function in older adults, although we did not find that walnut consumption was protective against age-related cognitive decline.”

Financial support: This research was funded by the California Walnut Commission.

Comment: Eating walnuts tracks with cognitive function in this sample, but has no particular effect on it.  As I read them, the conclusions put a positive spin on a null finding, a classic example of “interpretation bias.”  The Walnut Commission paid for the study and this interpretation helps to sell walnuts.  I think walnuts are great but wish the California Walnut Commission would stay out of this kind of marketing research.

Apr 19 2021

Industry-funded study of the week: avocados again and again

You might not think that avocados need any special sales efforts, but the Haas Avocado marketers are particularly aggressive in funding research to demonstrate the health benefits of this food.

I’ve written about Haas-funded avocado research previously (most recently, here and here) but here’s yet another, this time initiated by a tweet:

I think avocados are fine foods, love them, but wish their marketers would not do this.  Here’s the Good News Network headline: “An Avocado a Day May Keep Your Gut Microbes Happy, Study Shows.”  As always, the operative word is “may.”  The headline would be equally correct saying “may not.”

The study: Avocado Consumption Alters Gastrointestinal Bacteria Abundance and Microbial Metabolite Concentrations among Adults with Overweight or Obesity: A Randomized Controlled Trial. Sharon V Thompson, Melisa A Bailey, Andrew M Taylor, Jennifer L Kaczmarek, Annemarie R Mysonhimer, Caitlyn G Edwards, Ginger E Reeser, Nicholas A Burd, Naiman A Khan, Hannah D Holscher.  The Journal of Nutrition, Volume 151, Issue 4, April 2021, Pages 753–762.

Conclusions: “Daily avocado consumption resulted in lower fecal bile acid concentrations, greater fecal fatty acid and SCFAs, and greater relative abundances of bacteria capable of fiber fermentation, providing evidence that this nutrient-dense food affects digestive physiology, as well as the composition and metabolic functions of the intestinal microbiota.”

Funding: Support for this research was provided by the Hass Avocado Board and the USDA National Institute of Food and Agriculture, Hatch project 1009249.

Author disclosures: NAB, NAK, and HDH received grant funding from the Hass Avocado Board.

Comment: All fruits and vegetables provide nutritional value and the best way to get the nutrients you need is by eating a variety of them.  If you like avocados, include them in that variety.  If not, don’t.

The Haas marketers want you to think that avocados are a superfood.  Alas, there is no such thing.  All fruits and vegetables provide nutritional value.  By that criterion, all fruits and vegetables are superfoods.

Here’s an example of how Haas advertises:

Did you know fresh avocados can be part of the MyPlate food guide?

  • Make half your plate fruits and vegetables.

Avocados are a nutrient-dense fruit with naturally good fats and are easily incorporated into various meals and snacks. One serving (50g or one-third of a medium avocado) has only 80 calories and contributes nearly 20 vitamins, minerals, and phytonutrients along with dietary fiber.

The same could be said for most other fruits and vegetables, although most will be lower in calories.

Apr 5 2021

Industry-funded study of the week: Hummus this time

Dietary Patterns and Nutritional Status in Relation to Consumption of Chickpeas and Hummus in the U.S. Population.  by  Cara L. Frankenfeld and Taylor C. Wallace.   Appl. Sci. 202010(20), 7341; https://doi.org/10.3390/app10207341

Conclusion: ” Adults who consumed chickpeas and hummus were 48% and 62% less likely to have metabolic syndrome, respectively. Consuming chickpeas or hummus may be a practical means of improving diet quality and nutritional status. ”

Funding:  This research was funded by an investigator-initiated, unrestricted educational grant from Sabra Dipping Co., LLC.

Conflicts of Interest: T.C.W. has received prior research support from Sabra Dipping Co., LLC. C.L.F. declares no conflict of interest. The sponsor had no role in the study design; the collection, analysis, and interpretation of data; the writing of the manuscript; or the decision where to submit the paper for publication.

Comment: That’s what they all say about the sponsor’s role, despite substantial evidence to the contrary (in many other cases).  Sabra is owned by PepsiCo.

Hat tip: To Daniel Bowmn Simon for sending me this one.

Mar 15 2021

Annals of food industry marketing: potatoes

I like potatoes and they have plenty of nutritional value along with their calories, but their calories mainly come from starch—a rapidly digested carbohydrate.

The Harvard Food Pyramid puts potatoes in the “Eat Sparingly” category, right at the top with red meat, butter, and sugary beverages.

Potato industry marketers to the rescue!  Take a look at the website of Potatoes USA, which has as its mission developing marketing campaigns for the industry.

Industry participation is key to making any campaign a success. Here you’ll find marketing tools that will help you promote the positive potato nutrition message.  Find the tools that match your organization, whether you’re looking for resources for retailersmanufacturersconsumersfoodservice operators, or information on potato nutrition.

Here you can find a toolkit on how to market potatoes:

For years we’ve talked about why you can eat potatoes. Now we’re talking about why you should eat potatoes. Getting the whole industry involved is key to getting this message heard. Find the tools you need to support the process with events in your area.

I was interested in what they have to say about nutrition, of course: “Potatoes are more energy-packed than any other popular vegetable and provide the carbohydrates, potassium and energy you need to perform your best.”

The nutrition campaign focuses on energy for performance.  It provides a Nutrition Facts label that reassures you that one 5.3-ounce potato has only 110 calories.

It doesn’t say much—anything, really—about how Americans mostly eat potatoes, which happens to be as fries or chips.

It does provide tons of information about marketing methods, the research sponsored by the potato industry, and even issues regarding international trade—a goldmine if you are interested in this sort of thing.

If you just want to eat them, watch out for the added fats.  The bigger the potato—and the more butter and sour cream—the higher the calories.