Currently browsing posts about: Obesity

I subscribe to Obesity and Energetics Offerings because it’s a great way to keep up with current research and commentary on just about anything related to diet and activity.

One of the things I particularly like about it is its section called “Headline vs Study.”

Here is its most recent example:

• Headline: New Study Reveals COVID-19 Pandemic Fueling Pet Obesity.
• Press-release: No Formal Study Report Found. Survey of Pet Owner and Veterinarian Perception of Eating Behavior and Pet Obesity Patterns. No Pet Obesity Reported.

The headline, from Pet Food Industry magazine (an  unusually well written and edited source of information about this industry), refers to a survey of veterinarians done by Hill’s Pet Nutrition, a maker of pet foods.

According to veterinarians, more than 71% of pet professionals say the pandemic has impacted the way pets eat…Since the start of Covid-19, one third (33%) of pet parents with an overweight pet say their pet became overweight during the pandemic…veterinarians state that only 12% of pet parents proactively flag concerns with their pet’s weight. Moreover, nearly two in three veterinarians say pet parents act surprised (64%) or defensive (64%) upon learning about their pet’s weight issues.

Pet parents?  You know who you are.

What is this about?

IRONICALLY, TOO MUCH “TREAT LOVE” DURING THESE DIFFICULT TIMES IS THE MAIN CULPRIT.

Treats, as Mal Nesheim and I explain in our book about the pet food industry, Feed Your Pet Right, have calories, and those calories—just like the ones from any snack—add up.

Obesity in pets does just what it does in humans; it raises the risk of chronic disease, especially type-2 diabetes

A new study just out in the BMJ, which compared obesity in dogs to that of their owners, says:

Data indicated that owners of a dog with diabetes were more likely to develop type 2 diabetes during follow-up than owners of a dog without diabetes. It is possible that dogs with diabetes could serve as a sentinel for shared diabetogenic health behaviours and environmental exposures.

Pet parents: Walk those dogs!  Love them some other way!

Trust for America’s Health has just issued its annual report on obesity in America.

The full report is here.

The results are truly alarming, especially because obesity—and the conditions for which it increases risk—also increase the risk of poor Covid-19 outcome.

The U.S. adult obesity rate stands at 42.4 percent, the first time the national rate has passed the 40 percent mark, and further evidence of the country’s obesity crisis. The national adult obesity rate has increased by 26 percent since 2008…Rates of childhood obesity are also increasing with the latest data showing that 19.3 percent of U.S. young people, ages 2 to 19, have obesity. In the mid-1970s, 5.5 percent of young people had obesity.

The report has a special section on the link between food insecurity and obesity.

Food insecurity and obesity have many of the same risk factors (e.g., income or race/ethnicity) and often coexist in populations. Researchers have hypothesized several mechanisms for how food insecurity might lead to obesity. These include the direct limitations to a healthy diet that come from inadequate food affordability and/or availability; stress and anxiety about food insecurity
that generate higher levels of stress hormones, which heighten appetite; and a physiological response in which the body stores higher fat amounts in response to reduced food availability.

As always, this is a terrific source of current information about America’s increasingly prevalent health problem and what’s being done—and needs to be done—to solve it.

Nicolas Rasmussen.  Fat in the Fifties: America’s First Obesity Crisis.  Johns Hopkins University Press, 2019.  

I wrote a blurb for this book:

Fat in the Fifties is a riveting analysis of the rise and fall of early concerns about the health consequences of obesity.  Rasmussen’s history is indispensable for understanding the social, psychological, political, and environmental origins of today’s obesity “crisis.”

Even though the prevalence of obesity was quite low—by current standards—in the 1950s, Rasmussen documents widespread professional and public concern.  These concerns drifted away in the 1960s and 1970s, overtaken by efforts to prevent coronary heart disease, the leading cause of death.   At the time, obesity did not seem to be an important coronary risk factor.  Rasmussen explains how all this happened, and does it well.

I had a personal interest in this book.  My father died of a heart attack in 1950—at age 47.  It was no coincidence that he was also an extremely overweight chain smoker.  Rasmussen’s book provides the context for this particularly tragic aspect of my family history and I found his analysis helpful.

Research on this virus (officially SARS CoV-2, commonly COVID-19) is pouring out and filling every medical journal I typically read.  Here are a few recent articles on food-related aspects (some of these are not yet in print).

Obesity and its Implications for COVID-19 Mortality: The authors argue that the increased prevalence of obesity in Italy older adults as compared to its prevalence in China may account for the higher mortality observed in Italy.

Obesity is associated with decreased expiratory reserve volume, functional capacity and respiratory system compliance. In patients with increased abdominal obesity, pulmonary function is further compromised in supine patients by decreased aphragmatic excursion, making ventilation more difficult. Furthermore, increased inflammatory cytokines associated with obesity may contribute to the increased morbidity associated with obesity in COVID-19 infections.

Sudden and Complete Olfactory Loss Function as a Possible Symptom of COVID-19: This is a case study of a patient infected by SARS-CoV-2 whose presenting symptom was the sudden and complete loss of the ability to smell.

Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection:  “Our study suggests that loss of taste and smell is a strong predictor of having been infected by the COVID-19 virus. Also, the combination of symptoms that could be used to identify and isolate individuals includes anosmia, fever, persistent cough, diarrhoea, fatigue, abdominal pain and loss of appetite.”

COVID‐19 Related School Closings and Risk of Weight Gain Among Children:  “In short, we anticipate that the COVID‐19 pandemic will likely double out‐of‐school time this year for many children in the U.S. and will exacerbate the risk factors for weight gain associated with summer recess.”

Should COVID-19 Concern Nephrologists?  Why and to What Extent? The Emerging Impasse of Angiotensin Blockade:  This is the easiest-to-understand review of the science of this extensively studied virus I have been able to find.  It covers the basics along with detailed explanations of what this virus does, how it works, and where vaccines might operate.    To penetrate human cells, this virus seems to hijack a particular enzyme in the complicated renin-angiotensin system that regulates body fluid balance and blood pressure.

Despite these differences, several studies have reported that SARS-CoV-2 exploits the same membrane-bound angiotensin-converting enzyme 2 (ACE2) as SARS-CoV to gain access to its target cells, although it has greater binding affinity. ACE2 is a carboxypeptidase that preferentially removes carboxy-terminal hydrophobic or basic amino acids. ACE2 cleaves a single residue from angiotensin I (Ang I), generating Ang 1–9, and a single residue from angiotensin II (Ang II) to generate Ang 1–7, whose vasodilator, anti-proliferative, and anti-fibrotic functional effects oppose those of the Ang II generated by angiotensin converting enzyme (ACE).

Friday October 11 was World Obesity Day, which explains why so many groups are issuing reports on obesity prevalence, risks, costs, and prevention strategies.

I wrote about the one from the Trust for America’s Health, The State of Obesity, a few weeks ago.

Here are three more, just in.

1.  The Heavy Burden of Obesity: The Economics of Prevention.

This one was produced by the OECD (Organisation for Economic Co-operation and Development).  It finds: “Almost one in four people in OECD countries is currently obese. This epidemic has far-reaching consequences for individuals, society and the economy. Using microsimulation modelling, this book analyses the burden of obesity and overweight in 52 countries (including OECD, European Union and G20 countries), showing how overweight reduces life expectancy, increases healthcare costs, decreases workers’ productivity and lowers GDP.”

2.  Time to Solve Childhood Obesity   This is “An Independent Report by the Chief Medical Officer, 2019, Professor Dame Sally Davies in the U.K.  The cover deals with both cause and effect:

3.  State of Childhood Obesity: Helping All Children Grow Up Healthy.  The Robert Wood Johnson produced this one.

Its key findings:

• Obesity rates for youth ages 10 to 17 did not change much from 2016 (15%-16%).
• Racial and ethnic disparities persist as do disparities by income.
• Mississippi had the highest overall youth obesity rate (25.4%); Utah had the lowest (8.7%).

Comment:  Obesity is a global problem, not just one for the U.S.  Plenty of policies exist that could help make healthier food choices easier and less expensive.  But as the Lancet Global Syndemic report so clearly explained, doing something about obesity is hampered by weak (corporate-captured) government, food industry opposition, and weak civil society.  The first two are difficult to do anything about without attention to the third.  The clear need: strengthen civil society.  Let’s get to work on that.

Trust for America’s Health has just published its annual report on obesity, state by state.

As the home page puts it, “U.S. Obesity Rates Reach Historic Highs – Racial, Ethnic, Gender and Geographic Discrepancies Continue to Persist.”

The press release has an even more pointed headline: “U.S. Obesity Rates at Historic Highs – Nine States Reach Adult Obesity Rates of 35 Percent or More.”

The report highlights that obesity levels are closely tied to social and economic conditions and that individuals with lower incomes are more at risk. People of color, who are more likely to live in neighborhoods with few options for healthy foods and physical activity, and, are the target of widespread marketing of unhealthy foods, are at elevated risk.

What to do?

The report calls for sugary drink taxes, expanded SNAP and WIC Nutrition support programs and a built environment that encourages physical activity.

Buried in the report are suggestions for curbing food-industry marketing and other efforts to undermine public health initiatives.

• Keep industry out of dietary guidelines.
• Consider regulating food-industry marketing.
• Stop industry from preempting state public health laws.
• Reduce unhealthy food marketing to children.

Lots of good stuff here and well worth a read.

I spotted some tweets about this study from Washington Post writer Tamar Haspel, who has a sharp eye for this sort of thing.  Her first tweet said:

Her second tweet explained the problem:

So of course I had to look up the study.  It’s not one I would ordinarily have noticed because its title does not use the word “probiotic,” which typically refers to the live bacteria (in yogurt, for example).  The evidence for benefits of probiotics is iffy, so this study raises lots of questions.

Let’s take a look at it:

The Study:  Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Depommier C, et al.  Nature Medicine (2019) Letter | Published: 01 July 2019.

Conclusion: I’ve left out the statistics to make this easier to read:  “Compared to placebo, pasteurized A. muciniphila improved insulin sensitivity…, and reduced insulinemia…and plasma total cholesterol…. Pasteurized A. muciniphila supplementation slightly decreased body weight…compared to the placebo group, and fat mass…and hip circumference…compared to baseline….In conclusion, this proof-of-concept study…shows that the intervention was safe and well tolerated and that supplementation with A. muciniphila improves several metabolic parameters.”

Competing interests:  Five of the authors “are inventors of patent applications…filed with [patent offices in at least 12 countries]…dealing with the use of A. muciniphila and its components in the context of obesity and related disorders.” Two of the authors are cofounders of A-Mansia Biotech S.A., a Belgian company that sells A. muciniphila supplements, presumably as weight-loss supplements.

Comment: As Haspel points out, the subjects in this study were given either (a) live bacteria, (b) Pasteurized (and, therefore, mostly dead) bacteria, or (c) a placebo.  The Pasteurized ones were associated with metabolic benefits and weight loss.  Pasteurization is what gets done to milk to kill most—not all—of the living bacteria it contains.  In this study, Pasteurized bacteria had the same effect on the microbiome as the unpasteurized.  The point of the study was to show that the Pasteurized supplement would induce weight loss; the observed loss, however, was not statistically significant.   Nature Medicine‘s editors should know better.  So should the New York Times’ editors.  Haspel points out that the New York Times account of the study accepted its conclusion uncritically, headlining it “A Probiotic for Obesity?”  At least the headline included a question mark.  The article did not mention the authors’ patents or conflicts of interest; it should have.

Bottom line: If you want to keep your microbiome healthy, eat a healthy diet.

Kevin Hall at NIH has done a controlled diet study demonstrating that people who consume ultra-processed foods eat more calories—500 more a day (!)—and, therefore, gain weight.

Carlos Monteiro at the University of São Paulo and his colleagues explain how to identify ultra-processed foods.  

They also demonstrate that ultra-processed foods comprise nearly 60 percent of calorie intake.

No surprise.  Calories matter, as Mal Nesheim and I explained in our book Why Calories Count: From Science to Politics (and thanks Kevin for confirming what we wrote in that book).

The clear conclusions of this study have elicited a lot of attention.  Here’s my favorite from Francis Collins, the head of NIH and Kevin Hall’s boss, who also did a blog post:

Examples of media accounts (there were lots more)

• New York Times (this comes with pictures of the two different diets)
• Consumer Reports
• Mother Jones 
• Medical News Today
• NPR
• Center for Science in the Public Interest