Currently browsing posts about: HFCS (High Fructose Corn Syrup)

 I worry a lot about the ability of the FDA to set limits on the excess marketing practices of food companies.  The latest cause for worry is the seemingly trivial fuss over what to call High Fructose Corn Syrup (HFCS).

HFCS is not especially high in fructose (its fructose content is about the same as that of table sugar) but the term has gotten a bad reputation and food companies have begun to replace this sweetener with table sugar.

The Corn Refiners Association, the trade association that protects the interests of the makers of HFCS thinks it can solve that problem by getting the FDA to allow a name change from HFCS to “corn sugar” (see my previous comments on this issue).  The FDA has this request under consideration. 

In the meantime, the Corn Refiners are using “corn sugar” in advertisements on two websites, cornsugar.com and sweetsurprise.com.

Last week, the Associated Press (AP) reported that the FDA is taking a dim view of this behavior.   In a letter seen by the AP (but which I cannot find on the FDA website), the FDA has asked the Corn Refiners to cease and desist using “corn sugar” until the term receives regulatory approval.  

According to the AP account, which I have been unable to verify, the FDA:

Has no regulatory control over the corn association’s advertising because it is not selling a product but promoting an industry. The federal agency can prosecute companies that incorrectly label ingredients and [FDA official Barbara] Schneeman wrote that the FDA may launch enforcement action against food companies listing high fructose corn syrup as “corn sugar.”

The AP also said that internal FDA documents “indicate high-level skepticism” over the proposed name change. 

This, no doubt, is because “corn sugar” already exists as a regulatory term for dextrose which, in turn, is another name for the sugar, glucose, derived from corn. 

The AP says:

Michael Taylor, the FDA’s deputy commissioner for foods, wrote in an internal email that a previous attempt by the corn industry to change the name of high fructose corn syrup to just “corn syrup” was misleading, could have robbed consumers of important information and would invite ridicule.  “It would be affirmatively misleading to change the name of the ingredient after all this time, especially in light of the controversy surrounding it,” Taylor told colleagues in an email dated March 15, 2010.

Changing the name of HFCS to corn sugar is about marketing, not public health. If the FDA decides to approve the change, it will not alter the fact that about 60 pounds each of HFCS and table sugar are available per capita per year, and that Americans would be a lot healthier consuming a lot less of either one.

Philip Brasher of the Des Moines Register reports: the Western Sugar Cooperative has just filed suit against the Corn Refiners and corn processors to stop them for falsely advertising HFCS as “corn sugar.”

Oh please.  Western Sugar is trying to claim that HFCS is not sugar, when it most definitely is.  To sugar associations, which represent cane and beet producers, sugar means sucrose (the white stuff on the table).

When the Sugar Association threatened to sue me for saying that soft drinks had sugar and nothing else (when they also contained HFCS), I patiently explained the biochemistry.  If you would like to read what they said, I’ve posted the threatening letter and my response at the bottom of this link. Here’s the biochemistry:

• Sucrose: a double sugar of 50% glucose and 50% fructose linked together
• HFCS: a syrup of about 45% glucose and 55% fructose, separated

The 5% differences are biologically insignificant and the body can’t tell them apart.

I never heard from the Sugar Association again, but I try to to remember to say sugars, plural.

Whether the FDA should allow the defendants to change the name of HFCS to Corn Sugar is a matter of some debate (see previous posts and comments on them).  The FDA will make its decision in due course.

In the meantime, this lawsuit is about marketing competition among sources of sugars (plural).  It has nothing to do with health.

It’s fun to watch lobbying in action, especially when it is so overt.  I’ve just been sent a copy of this “Dear Colleague” letter organized by the Corn Refiners’ Association.  The letter comes from two members of Congress.  It asks other members of Congress to write the FDA to change the name of High Fructose Corn Syrup to Corn Sugar.

From the Corn Refiners:

Dear [Member of Congress],

As your Member’s district has a strong interest in corn or corn sweetener, I am sending you this Dear Colleague letter for your consideration. Representatives Tom Latham and Daniel Lipinksi are circulating the letter, pasted below, for your boss’ consideration. The Corn Refiners Association, with support from the National Corn Growers Association has petitioned the FDA to allow use of the name ‘corn sugar’ as an alternative to High Fructose Corn Syrup on ingredient labels. This letter outlines our support for this petition.

From Representatives Tom Latham (Rep–Iowa) and Daniel Lipinski (Dem–Illinois):

Dear [FDA] Commissioner Margaret A. Hamburg,

We write to express our support for a petition to use “corn sugar” as an alternate name for high fructose corn syrup on ingredient labels that would help consumers avoid confusion about the foods they buy. We endorse prompt review and approval of petition FDA-2010-P-0491, which was submitted by the Corn Refiners Association.

The petition requests the term “corn sugar” be permitted as an optional name for high fructose corn syrup on ingredient labels to avoid customer misconceptions. Evidence suggests that current terminology encourages misunderstanding in the marketplace regarding the nutritional profile and composition of corn sweeteners, and the alternate name would help dispel some of the confusion. According to a recent nationwide MSR Group survey, around 70 percent of Americans surveyed could not correctly identify high fructose corn syrup when presented with the American Dietetic Association’s definition. The same research found that “corn sugar” is a better alternative because it gives consumers a more accurate understanding of the product’s fructose content, calories and sweetness.

The product used in most foods—including yogurts, baked goods, condiments, and salad dressings—actually has the lowest fructose content of any sweetener on the market. Despite this fact, MSR Group’s research showed that most Americans believe high fructose corn syrup to be higher in fructose than table sugar; misinformation perpetuated by the substance’s name.

High fructose corn syrup is made from corn grown here in the United States by a critical industry that provides Americans thousands of good jobs. Equally important, it enables American consumers greater choice and affordability at the grocery store. Unfortunately, significant misperceptions about this ingredient have circulated in the media, in large part due to its name.

The American Medical Association has indicated that sugar and high fructose corn syrup have similar compositions, while the American Dietetic Association has determined that these two sweeteners are nutritionally equivalent and indistinguishable to the human body. These facts are sometimes lost in the confusion surrounding the ingredient’s name, and we believe that allowing use of the alternate term, “corn sugar,” would allow consumers to make accurate decisions about added sugars in their diets.

We support expeditious review and approval of this petition.

If enough members of Congress write such letters, the FDA is likely to pay attention, no?

A colleague pointed out to me today that I am listed nine times on the Corn Refiners Association website as supporting its petition to the FDA to change the name of High Fructose Corn Syrup (HFCS) to corn sugar.

When the idea first came up, I didn’t think it mattered much.  But as I had to add more and more postscripts to my post on the issue, and as I read the comments on it, I was persuaded otherwise.   On balance, the arguments against changing the name outweigh the idea that it doesn’t matter (it matters to the Corn Refiners of course).

The FDA is collecting comments on the name change on its website.  I filed this comment today:

The FDA should deny the Corn Refiners petition to change the name of High Fructose Corn Syrup (HFCS) to corn sugar.

I understand that the Corn Refiners Association uses my comments on its website to support its position. The website quotes comments I have made to the effect that HFCS is biochemically equivalent to sucrose. It is. But I do not believe that biochemical equivalence is a good reason for the FDA to agree to a name change at this point.

It is highly unlikely that public misunderstanding of nutritional biochemistry and the differential physiological effects of glucose vs. fructose will be addressed and corrected by changing the name of HFCS to corn sugar.

Therefore, the name change is not in the public interest. Its only purpose is to further the commercial interests of members of the Corn Refiners, and that is not one the FDA should be concerned about.

If you have thoughts about the petition, nothing could be easier than telling the FDA what you think:

1. Click on this link.

2. Look on the left side of the page “Results,” “Corn Refiners Association – Citizens Petition,” and on the right side a link that says “Submit a Comment.”

3. Click on “Submit a Comment.”  Fill out the form with your name and affiliation.  Type in your comment.  If a box comes up saying that you are taking too long, click OK and it will give you more time.

My understanding is that there is no particular deadline but rumors are that the FDA will consider all comments submitted by the end of this week.

I’ve been saying for ages that the sugar composition of high fructose corn syrup (HFCS) is no different from that of table sugar (sucrose).

Oops.  A new study in the journal, Obesity, actually measured the amounts and kinds of sugars in 23 kinds of HFCS-sweetened drinks.

The findings are summarized in a fact sheet:

• The sugar content varied widely from amounts stated on labels.  Some drinks had 15% less sugar than labeled, but others had as much as 30% more.
• On average, the drinks had 18% more fructose than expected.
• Several brands of sodas seemed to be made with HFCS that is 65% fructose, not 55%.
• The average amount of fructose in the drinks was 59%.

The press release points out one other finding.  You know how everyone thinks Mexican Coca-Cola is so much more delicious than American Coke because it is made with table sugar (sucrose), not HFCS?  Oops again.  The investigators could not find any sucrose in the Coke, but did find plenty of glucose and fructose.  This suggests that Mexican Coke is also made with HFCS (or it could also mean that the sucrose had been split into its constituent glucose and fructose).

To review the biochemistry: sucrose is a double sugar of glucose and fructose bonded together.  HFCS is glucose and fructose, separated.  The sucrose bond is quickly split in the intestine and its glucose and fructose are the same as those in HFCS.

The metabolic problems that result from sugar intake are mostly due to the fructose content.  Less is better for health.  More is better for the soft drink industry, however.  Fructose is sweeter than either glucose or sucrose, and sweet is what sells sodas.

At most, HFCS is supposed to be 55% fructose, as compared to the 50% in table sugar.  Most foods and drinks are supposed to be  using HFCS that is 42% fructose.  A percentage of 55 is not much different biologically than 50, which is why the assumption has been that there is no biologically meaningful difference between HFCS and table sugar.   This study, if confirmed, means that this supposition may need some rethinking.

The study names the beverages that contain 65% fructose: Coke, Pepsi, Sprite. It identifies Dr. Pepper, Gatorade, and Arizona Ice Tea as containing close to 60% fructose.

If, in fact, the percentage of fructose is higher than advertised, it’s another good reason to avoid sugar-sweetened beverages.

Addition and possible caution:  I’ve now heard separately from two experts on measuring sugars in beverages who point out serious flaws in the methods used in this study:

• The results are based on one beverage sample, analyzed once.   Analytical methods invariably produce ranges of values and require multiple samples and analyses.
• Measuring sugars in beverages is technically challenging and there are several possible methods, some of which give more accurate results than others.  Although the paper says the investigators used standard methods, it does not specify which.
• The methods used did not seem to detect the small starches or maltose that are always present in HFCS.  If the methods “read” the little starches as fructose, the percentage could easily have been 59 rather than 55.
• The drinks that contained 65% fructose were bottled drinks, and that is a concern.  The fountain drinks are mixed by the company–McDonald’s or Burger King–and could have been made too concentrated by whoever did the mixing.
• The failure to find sucrose in Mexican Coca-Cola could be two to two reasons: the Coke is old and the sucrose “inverted” (split into glucose and fructose), or the company used HFCS instead of sucrose.

The bottom line remains the same: it’s best not to eat too much sugar or any kind.

Addition, October 27: Cara Wilking, an attorney with the Public Health Advocacy Institute in Boston, notes that this study raises the possibility that HFCS violates federal prohibitions against:

• False and misleading food labeling
• Food adulteration
• False and misleading advertising

It will be interesting to follow how the lawyers deal with these issues.

Thanks to alert reader Glen for pointing out that the FDA already has a regulation for Corn Sugar in the Code of Federal Regulations, under food substances Generally Recognized as Safe (GRAS).  CFR Section 184.1857 reads:

(a) corn sugar (C6H12O6, CAS Reg. No. 50-99-7), commonly called D-glucose or dextrose, is the chemical [alpha]-D-glucopyranose. It occurs as the anhydrous or the monohydrate form and is produced by the complete hydrolysis of corn starch with safe and suitable acids or enzymes, followed by refinement and crystallization from the resulting hydrolysate.

(b) The ingredient meets the specifications of the Food Chemicals Codex, 3d Ed. (1981), pp. 97-98 under the heading “Dextrose….”

(c) In accordance with 184.1(b)(1), the ingredient is used in food with no limitation other than current good manufacturing practice.

The Corn Refiners have just petitioned the FDA to be allowed to use the name Corn Sugar to apply to both glucose/dextrose and High Fructose Corn Syrup (HFCS).  But the existing definition seems to exclude HFCS.  While HFCS is about half glucose, it is also about half fructose, and its manufacture from corn starch requires one more enzyme.

A reminder about sugar chemistry:

• Glucose is the sugar in blood, and dextrose is the name given to glucose produced from corn but biochemically they are identical.
• Fructose is the principal sugar in fruit.  In fruit, it raises no issues because it is accompanied by nutrients and fiber.
• Sucrose is table sugar.  It is a double sugar, containing one part each of glucose (50%) and fructose (50%), chemically bound together.  Enzymes in the intestine quickly and efficiently split sucrose into glucose and fructose, which are absorbed into the body as single sugars.
• HFCS is made from corn starch.  It contains roughly equivalent amounts of glucose (45 to 58%) and fructose (42 to 55%).

HFCS raises several issues, health and otherwise:

• Quantity: the U.S. food supply provides to every American (all ages) about 60 pounds of sucrose and another 60 pounds of HFCS each year.  This is way more than is good for health.  Sugars of any kind provide calories but no nutrients.
• Fructose: increasing evidence suggests that the metabolism of fructose–which differs from that of glucose–is associated with abnormalities.  This means that it is best to reduce intake of fructose from table sugar as well as HFCS.
• Farm subsidies: these go to large corn producers and have kept down the cost of HFCS relative to that of sucrose.  The use of corn to make ethanol has raised the relative price of HFCS.
• Genetic modification: Most corn grown in the United States is genetically modified to resist insects or herbicides.

From a health standpoint, it makes no difference whether the sweetener is sucrose or HFCS.

As for agave sugar as a substitute: it can have much higher concentrations of fructose than either sucrose or HFCS but its labels do not give percentages so you have no way to know how much.

Given all this, what’s your guess about what the FDA will decide?

The Corn Refiners Association is asking the FDA to allow a change in the name of their embattled sweetener from High Fructose Corn Syrup (HFCS) to Corn Sugar.

Of course they want this change.  HFCS is the new trans fat.  Everyone thinks HFCS is poison.

For the record once again, HFCS is not poison.  It is just a mixture of glucose and fructose in almost the same proportions as table sugar, sucrose.

Mind you, I am not fond of the idea that Americans use 60 pounds of corn sweeteners per capita per year and another 60 pounds of table sugar, and I am not particularly eager to help the Corn Refiners sell more of their stuff.

But you can understand the Corn Refiners’ pain: food companies are getting rid of HFCS as fast as they can and replacing it with table sugar.

This move is driven not only by bad press, but also by the fact that the price differential has all but disappeared.  HFCS started out at one-third the cost of table sugar.  Growing corn to make alcohol changed all that.

Let’s give the Corn Refiners credit for calling a sugar a sugar.  I would prefer Corn Sugars (plural) to indicate that it is a mixture of glucose and fructose.  But as long as they don’t call it “natural,” the change is OK with me.

But I’m wondering if it’s too late.  Maybe anything with the word “corn” in it will be enough to turn people off?  According to the Associated Press, the Corn Refiners are already using Corn Sugar in their advertising, so we will soon find out.

Your thoughts?

Additional historical note: Thanks to a reader, candyprofessor.com, who is evidently a fount of information about such things, for this enlightening tidbit:

In the early 1900s, what we call “corn syrup” was sold as “glucose,” the chemical name for the type of sugar derived from corn starches. Food reformers pointed to the “glucose” in candy and claimed that candy was poisoned with “glue.”  So the corn producers lobbied to have “glucose” renamed “corn syrup.” Sounds like we’re coming around again full circle…now “corn syrup” is poison!

Updates, September 15: Tara Parker-Pope writes about this in the New York Times (and quotes me).  So does Michele Simon on her blog.  As usual, Simon says it like it is:

As a result of this demonizing, we are now in the ridiculous situation where food companies are falling over each other to remove HFCS from their products, slap on a natural label, and get brownie points for helping Americans eat better….Only Big Food would find a way to make a product full of refined white sugar (which at one time was also demonized) seem like a healthy alternative. It’s like I always say, the food industry is very good at taking criticism and turning it into a marketing opportunity.

How, I wonder, will the Corn Refiners manage this one?  Not so easily, judging from readers’ comments.

Update, September 16: Fo0dNavigator.com reports that more than half of Americans surveyed will not buy products with HFCS.  Market researchers are advising food companies to get rid of it.

I can hardly believe that Princeton sent out a press release yesterday announcing the results of this rat study.  The press release says: “Rats with access to high-fructose corn syrup gained significantly more weight than those with access to table sugar, even when their overall caloric intake was the same.”

How they came to these conclusions is beyond me. Here’s the original paper.

It has long been known that feeding sugars to rats makes them eat more and gain weight.  But, as summarized in Table 1 in the paper, the researchers did only two experiments that actually compared the effects of HFCS to sucrose on weight gain, and these gave inconsistent results.  Their other experiments compared HFCS to chow alone.

The study is extremely complicated and confusingly described.  As best as I can tell, here’s what they found:

1.  The first study used 10 male rats in each group and observed them for 8 weeks.  At the end of the study, the rats fed chow alone weighed 462 grams.  The rats fed sucrose plus chow weighed 477±9 grams.   The rats fed HFCS plus chow weighed 502±11 grams.   The authors say the difference between 477 and 502 grams is statistically significant.  But these rats were offered the sugars for 12 hours per day.  The rats fed HFCS for 24 hours per day, which should be expected to be fatter, were not.  They weighed less (470 grams) than the rats fed sucrose for 12 hours per day.  So these results are inconsistent.

2.  The second study did not compare rats eating HFCS to rats eating sucrose.  It just looked at the effects of HFCS in groups of 8 male rats.

3.  The third study used female rats (number not given) and observed them for 7 months.  At the end of the study period, female rats fed HFCS plus chow for 12 hours a day weighed 323±9 grams.  Female rats fed sucrose plus chow under the same conditions weighed 333±10 grams.   This result is not statistically significant.

Although the authors say calorie intake was the same, they do not report calories consumed nor do they discuss how they determined  that calorie intake was the same.  This is an important oversight because measuring the caloric intake of lab rats is notoriously difficult to do (they are messy).

So, I’m skeptical.  I don’t think the study produces convincing evidence of a difference between the effects of HFCS and sucrose on the body weight of rats.  I’m afraid I have to agree with the Corn Refiners on this one.

So does HFCS make rats fat?  Sure if you feed them too many calories altogether.  Sucrose will do that too.

NOTE 3/26: see point-by-point response to this post by Bart Hoebel, one of the authors of the study, in the Comments below.

Addition, November 23: Thanks to Jeff Walker, professor of Biology at the University of Southern Maine, Portland, for doing a detailed critique of the study, most thoughtful and well worth a look.